The drug Metformin makes the body to get rid of the threat of cell debris, which appeared because of the radiation.The drug Metformin makes the body to get rid of the threat of cell debris, which appeared because of the radiation.
Metformin is one of the most well-known medicines against type II diabetes: it increases sensitivity of cells to insulin, and the insulin, in turn, causes cells to absorb glucose from the blood. But Metformin has other beneficial properties. For example, it is known that it inhibits the aging process, it can work against malignant cells and that it increases the effectiveness of radiation therapy of tumors.
Another benefit of Metformin is described in Mutation Research/Genetic Toxicology and Environmental mutagenesis is researchers from the Institute of theoretical and experimental Biophysics (ITEB) RAS. Earlier the staff of the laboratory of radiation molecular biology ITEB found that Metformin stimulates apoptosis and autophagy. Apoptosis is called program cell death, which is triggered when a cell goes haywire and threatens trouble for others (for example, if cellular DNA has accumulated too much damage, and the cell is in danger of becoming malignant). Autophagy is the destruction of defective organelles within the cell. For example, if you take the mitochondria, which are engaged in that use oxygen to produce cell energy, as a by-product constantly emerging oxygen radicals are very aggressive molecules-oxidants. The mitochondria of these radicals and neutralize, but it happens that neutralizing the biochemical mechanism fails, and the mitochondria becomes simply dangerous – in this case, the cell recycles its through autophagy.
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Thus, Metformin, by activating apoptosis and autophagy, facilitating the removal of defective cells and cellular organelles. We know that timely cleaning of cellular and molecular debris helps to survive stress conditions, and therefore in their new experiments, Serajuddin Abdullayev and his colleagues decided to test how the drug stress, namely, ionizing radiation.
Was the Metformin really helped rats survive x-irradiation, and in the urine of animals, which after irradiation were injected the medicine, there is a lot of DNA, both nuclear and mitochondrial. DNA in urine was produced by the destruction of cells, and that it was more while using Metformin, talked about the fact that it activates the garbage-disposal system, helping the body get rid of dangerous cells and damaged organelles that can run some pathology. Perhaps in the future, Metformin will use as a radioprotector, but first you need to make sure in this as it is quite effective not only in rats but also in humans.
This work was supported by RFBR grant.
According to the press service of ITEB RAS.